Molecular Biology of Basal and Squamous Cell Carcinomas 

Molecular Biology of Basal and Squamous Cell Carcinomas 

Variations in drug sensitivity between two-dimensional and three-dimensional custom strategies in triple-negative breast most cancers cell strains

Three-dimensional (3D) custom shows tumor biology complexities in distinction with two-dimensional (2D) custom. Thus, 3D custom has attracted consideration in cell biology analysis along with drug sensitivity exams.

Herein, we investigated variations in anticancer drug sensitivities between 2D and 3D custom strategies in triple-negative breast most cancers (TNBC) cell strains. 13 TNBC cell strains have been maintained in 2D and 3D cultures for Three days sooner than drug publicity. Cell morphology throughout the 3D custom was examined by phase-contrast microscopy.

Sensitivities to epirubicin (EPI), cisplatin (CDDP), and docetaxel (DTX) have been investigated by cell viability assay in every cultures and in distinction. The IC50s of all Three treatment have been significantly better throughout the 3D custom than throughout the 2D custom in most cell strains.

These have been correlated between the 2D and 3D cultures in EPI (R = 0.555) and CDDP (R = 0.955), nevertheless not in DTX (R = 0.221). Spherical spheroid-forming cells have been further proof in opposition to brokers than grape-like kinds. In conclusion, 3D custom was further proof in opposition to all Three treatment than 2D custom in most TNBC cell strains. Sensitivity to CDDP was extraordinarily correlated between the 2D and 3D cultures, nevertheless to not DTX. 2D custom is also acceptable for sensitivity check out for DNA-damaging brokers.

Molecular Biology of Basal and Squamous Cell Carcinomas 

The prevalent keratinocyte-derived neoplasms of the pores and skin are basal cell carcinoma and squamous cell carcinoma. Each so-called non-melanoma pores and skin cancers comprise the commonest cancers in people by far. Widespread threat elements for each tumor entities embrace solar publicity, DNA restore deficiencies resulting in chromosomal instability, or immunosuppression.

But, elementary variations within the improvement of the 2 completely different entities have been and are at the moment unveiled. The constitutive activation of the sonic hedgehog signaling pathway by acquired mutations within the PTCH and SMO genes seems to signify the early basal cell carcinoma developmental determinant.

Though different signaling pathways are additionally affected, small hedgehog inhibitory molecules evolve as probably the most promising basal cell carcinoma remedy choices systemically in addition to topically in present scientific trials. For squamous cell carcinoma improvement, mutations within the p53 gene, particularly UV-induced mutations, have been recognized as early occasions.

But, different signaling pathways together with epidermal development issue receptor, RAS, Fyn, or p16INK4a signaling might play vital roles in squamous cell carcinoma improvement. The improved understanding of the molecular occasions main to completely different tumor entities by de-differentiation of the identical cell sort has begun to pave the way in which for modulating new molecular targets therapeutically with small molecules.

stemcelldocs
stemcelldocs

PiBlue Phosphate Assay Kit

POPB-500 500
EUR 304.8
Description: High-throµghput phosphate assay using malachite green method at 620nm. Kit size: 500 tests. Detection limit: 0.4 µM. Shelf life: 12 months. Shipping: ambient temp; storage: 4°C.

Phosphate Assay Kit (Fluorometric)

STA-686 1000 assays
EUR 582
Description: Our Phosphate Assay Kit (Fluorometric) measures total inorganic phosphate present in lysates, solutions, food, or biological samples in a 96-well fluorescence-based plate reader. 1000 assays/kit.

PBlue Phosphate Assay Kit

Z5030013 500 assays
EUR 466.8
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

NanoMolar Phosphate Assay Kit

NPA1000 1000 assays
EUR 168.93
Description: This product includes 100 ml of Reagent P1 and 1 ml of 100 x Reagent P2 and 0.1 ml of 1 mM potassium phosphate (KH2PO4). It is for 1000 assays using 96-well plates (100 ul of sample volume) or 4000 assays using 384-well plates (25 l of sample volume). The following protocol is for assays using 96-well plates. Cuvettes may also be used for the measurement.

Peroxide assay, colorimetric micro assay kit, 96 test, Quantitative

1350-POX-1 1 kit
EUR 489.6

Peroxidase assay, colorimetric micro assay kit, 96 test, Quantitative

1360-PAS-1 1 kit
EUR 634.8

Phosphoprotein Phosphate Estimation Assay Kit

BSP061 2000Assays, 2000preps
EUR 110.11

Glucose-6-Phosphate Assay Kit

55R-1487 100 assays
EUR 847.2
Description: Assay Kit for detection of Glucose-6-Phosphate in the research laboratory

Sucrose Phosphate Synthase Assay Kit

abx298805-100Assays 100 Assays
EUR 754.8

Malachite Green Phosphate Assay Kit

abx298878-100Assays 100 Assays
EUR 453.6

PicoProbe? Phosphate Fluorometric Assay Kit

K419-100
EUR 535.2

Malachite Green Phosphate Assay Kit

POMG-25H 2500
EUR 330
Description: High-throµghput phosphate assay using malachite green method at 620nm. Kit size: 2500 tests. Detection limit: 0.02 µM. Shelf life: 12 months. Shipping: ambient temp; storage: 4°C.

Malachite Green Phosphate Assay Kit

Z5030012 2,500 assays
EUR 410.4
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

Malachite Green Phosphate Assay kit

65-POMG-25H 2500 tests
EUR 333

Phosphate (ortho/total) cuvette test

LCK349 EACH
EUR 203.01

Phosphate Test 0.5-5mg/L

WAT3653 EACH
EUR 203.01

NATtrol Zika Virus Stock (Qualitative) (1 mL)

TEST 1 mL
EUR 1327.97
Description: Please contact Gentaur in order to receive the datasheet of the product.

Glutathione (GSH) Assay, Enzymatic colorimetric assay kit, 96 test, Quantitative

1250-GSH-1 1 kit
EUR 489.6

MESG *Phosphate assay reagent*

21600 5 mg
EUR 138

MicroMolar Phosphate Assay Reagent

MPA3000 3000 assays
EUR 168.93
Description: This product includes 450 ml of reagent. It is for 3000 to 5000 assays using 96-well plates or more than 10,000 assays using 384-well plates. It can also be used for measurement of phosphate concentrations using cuvettes and a spectrophotometer.

MESG *Phosphate assay reagent*

21600-1MG 1 mg
EUR 77

PicoProbe Glucose-6-Phosphate Assay Kit

55R-1495 100 assays
EUR 909.6
Description: Assay Kit for detection of Glucose-6-Phosphate in the research laboratory

PicoProbe Fructose-6-Phosphate Assay Kit

55R-1496 100 assays
EUR 909.6
Description: Assay Kit for detection of Fructose-6-Phosphate in the research laboratory

Glucose-6-Phosphate Dehydrogenase Assay Kit

55R-1520 100 assays
EUR 847.2
Description: Assay Kit for detection of Glucose-6-Phosphate Dehydrogenase in the research laboratory

Glucose-6-Phosphate Dehydrogenase Assay Kit

abx298812-100Assays 100 Assays
EUR 510

EnzyChrom Glucose-6-Phosphate Assay Kit

EG6P-100 100
EUR 486
Description: For quantitative colorimetric determination of Glucose-6-Phosphate concentration and evaluation of drug effects on its metabolism. Method: OD460nm. Samples: plasma, serum,tissue and culture media etc. Species: all. Procedure: 20 min. Size: 100 tests. Dete

Glucose-6-Phosphate Colorimetric Assay Kit

K2208-100 100 assays
EUR 634.8

Glucose-6-Phosphate Fluorometric Assay Kit

K2220-100 100 assays
EUR 718.8

Fructose-6-Phosphate Fluorometric Assay Kit

K2222-100 100 assays
EUR 718.8

Glucose-1-Phosphate Colorimetric Assay Kit

K697-100
EUR 660

Glucose-6-Phosphate Colorimetric Assay Kit

K657-100
EUR 614.4

Glutathione Peroxidase Assay (GPX), Enzymatic colorimetric assay kit, 96 test, Quantitative

1240-GPX-1 1 kit
EUR 708

Glucose colorimetric micro assay kit, 96 test, Quantitative

1380-GLC-1 1 kit
EUR 343.2

Cholesterol colorimetric micro assay kit, 96 test, Quantitative

1390-CHL-1 1 kit
EUR 634.8

Cholesterol Fluorometric micro assay kit, 96 test, Quantitative

1395-CHL-1 1 kit
EUR 416.4

Glycogen fluorometric micro assay kit, 96 test, Quantitative

1530-GLY-1 1 kit
EUR 634.8

Hemoglobin colorimetric micro assay kit, 96 test, Quantitative

1540-HEM-1 1 kit
EUR 343.2

Triglyceride colorimetric micro assay kit, 96 test, Quantitative

1550-TGL-1 1 kit
EUR 343.2

Phosphate Test 1.6-30mg per L

WAT3640 1KIT
EUR 131.51

Phosphate Test 0.05 to 5.00mg/L

WAT4328 PK25
EUR 126.54

Phosphate Test 0.5 to 25.00mg/L

WAT4330 PK25
EUR 126.54

Phosphate Test 3.0 to 307.0mg/L

WAT4332 PK100
EUR 178.98

Glycerol-3-Phosphate (G3P) Assay Kit (Colorimetric)

MET-5075 100 assays
EUR 567.6

Glycerol-3-Phosphate (G3P) Assay Kit (Fluorometric)

MET-5076 100 assays
EUR 609.6

Glycerol-3-Phosphate (G3P) Colorimetric Assay Kit

K641-100
EUR 652.8

PicoProbe? Glucose-6-Phosphate Fluorometric Assay Kit

K687-100
EUR 660

PicoProbe? Fructose-6-Phosphate Fluorometric Assay Kit

K689-100
EUR 660

PicoProbe? Dihydroxyacetone Phosphate (DHAP) Fluorometric Assay Kit

K673-100
EUR 927.6

PicoProbeTM Glycerol-3-Phosphate Assay Kit (Fluorometric)

K196-100
EUR 679.2

BCA Protein Assay Kit (Test Tube) - Reducing Agent Compatible

K819-250
EUR 392.4

Nitric Oxide Synthase (NOS) enzyme assay, colorimetric micro assay kit, 96 test, Quantitative

1290-NOS-1 1 kit
EUR 781.2

PhosphoWorks™ Fluorimetric Phosphate Assay Kit *Red Fluorescence*

21660 125 Tests
EUR 367.2

PhosphoWorks™ Colorimetric Phosphate Assay Kit *Blue Color*

21665 1000 Tests
EUR 262.8

Amplite™ Fluorimetric Glucose-6-Phosphate Assay Kit

13804 200 Tests
EUR 367.2

Amplite™ Colorimetric Glucose-6-Phosphate Assay Kit

13805 200 Tests
EUR 367.2

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Activity Assay Kit

MET-5078 200 assays
EUR 609.6

Glucose-6-Phosphate Dehydrogenase (G6PDH) Activity Assay Kit

MET-5081 100 assays
EUR 470.4

Glycerol-3-Phosphate Dehydrogenase Activity Colorimetric Assay Kit

K640-100
EUR 783.6

Triose Phosphate Isomerase (TPI) Activity Colorimetric Assay Kit

K670-100
EUR 783.6

Glucose-6-Phosphate Dehydrogenase Activity Colorimetric Assay Kit

K757-100
EUR 614.4

Glucose-6-Phosphate Dehydrogenase Activity Colorimetric Assay Kit

K2172-100 100 assays
EUR 619.2

PhosphoWorks™ Fluorimetric Phosphate Assay Kit *Red Fluorescence*

21661 1250 Tests
EUR 2197

Ketone Body Enzymatic colorimetric micro assay kit, 96 test, Quantitative

1260-KTN-1 1 kit
EUR 489.6

PhosphoWorks™ Colorimetric MESG Phosphate Assay Kit *UV absorption*

21659 200 Tests
EUR 367.2

Amplite™ Fluorimetric Glycerol 3-Phosphate (G3P) Assay Kit

13837 200 Tests
EUR 420

Amplite™ Colorimetric Glycerol 3-Phosphate (G3P) Assay Kit

13838 200 Tests
EUR 420

PPDK (Pyruvate, phosphate dikinase) Activity Assay Kit (Fluorometric/Colorimetric)

K456-100
EUR 574.8

PicoProbe? Glucose-6-Phosphate Dehydrogenase Activity Assay Kit (Fluorometric)

K751-100
EUR 744

Total Antioxidant Capacity (TAC), colorimetric micro assay kit, 96 test, Quantitative

1370-TAS-1 1 kit
EUR 634.8

Amplite™ Fluorimetric Glucose-6-Phosphate Dehydrogenase (G6PD) Assay Kit

13806 200 Tests
EUR 367.2

Amplite™ Colorimetric Glucose-6-Phosphate Dehydrogenase (G6PD) Assay Kit

13807 200 Tests
EUR 367.2

Anti-SARS-CoV-2 Neutralization Antibody Test Kit (Enzyme-linked immunosorbent assay)

CP04012 96T/5*96T Ask for price
Description: It is a semi quantitative competition ELISA kit to detect the Anti-SARS-CoV-2 Neutralization Antibody in human serum or plasma. The micro test plate provided in this kit is pre-coated with recombinant human ACE2. During the reaction, the SARS-CoV-2 neutralization antibody in the standard & sample diluent pretreated samples or controls competes with a fixed amount of human ACE2 on the solid phase supporter for sites on the Horseradish peroxidase (HRP) conjugated recombinant SARS-CoV-2 RBD fragment (HRP-RBD). After 37℃incubation, the unbound HRP-RBD as well as any HRP-RBD bound to non-neutralization antibody will be captured on the plate and eventually form the ACE2-RBD-HRP complex, while the circulating neutralization antibodies HRP-RBD complexes remain in the supernatant and are removed during washing. Then a TMB substrate solution is added to each well. The enzyme-substrate reaction is terminated by the addition of stop solution and the color change is measured spectrophotometrically at a wavelength of 450 nm ± 2 nm.

Ascorbic Acid/Ascorbate (Vitmain C) fluorometric micro assay kit, 96 test, Quantitative

1520-ASC-1 1 kit
EUR 634.8

Thiobarbituric acid reactive substances (TBARS) colorimetric micro assay kit, 96 test, Quantitative

1270-TBA-1 1 kit
EUR 489.6

Nitric Oxide (NO/nitrate/nitrite) colorimetric micro assay kit, 96 test, Quantitative

1280-NOX-1 1 kit
EUR 634.8

Human PDXP(Pyridoxal phosphate phosphatase) ELISA Kit

EH1894 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.375 ng/ml

Human S1P(Sphingosine 1 Phosphate) ELISA Kit

EH2564 96T
EUR 628.92
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 1.875 ng/ml

Frit Kit

FRIT-KIT 1each
EUR 148.8
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

Column Packing Kit

PACK-KIT 1pack
EUR 1242
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

PCR Mycoplasma Detection Kit

M034-Kit Kit
EUR 319.2

Mouse Gapdh(Glyceraldehyde-3-phosphate dehydrogenase) ELISA Kit

EM0700 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.188 ng/ml

Mouse G6PD(Glucose 6 Phosphate Dehydrogenase) ELISA Kit

EM1048 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml

Mouse GPI(Glucose 6 Phosphate Isomerase) ELISA Kit

EM1086 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.188 ng/ml

Human GAPDH(Glyceraldehyde-3-phosphate dehydrogenase) ELISA Kit

EH2006 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human GPI(Glucose 6 Phosphate Isomerase) ELISA Kit

EH3165 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

Rat Gpi(Glucose-6-phosphate isomerase) ELISA Kit

ER0359 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 46.9pg/ml

Rat G6PD(Glucose 6 Phosphate Dehydrogenase) ELISA Kit

ER0968 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 9.375pg/ml

Human RPIA(Ribose-5-phosphate isomerase) ELISA Kit

EH1486 96T
EUR 681.12
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 0.938 ng/ml

Melamine Rapid Test Kit

abx092011-50tests 50 tests
EUR 444

NDV rapid test kit

RG15-03 1 box
EUR 166.86
Description: Please check the datasheet of NDV rapid test kit before using the test.

Hach Test Kit CYANIDE

LCK315 EACH
EUR 144.28

Hach Test Kit FLUORIDE

LCK323 EACH
EUR 136.62

Hach Test Kit COPPER

LCK329 EACH
EUR 178.75

Hach Test Kit NICKEL

LCK337 EACH
EUR 183.86

Hach Test Kit SULPHIDE

LCK653 EACH
EUR 163.43

Staphyloslide Latex Test Kit

240915 PK100
EUR 272.46

Elga Chlorine Test Kit

WAT4098 EACH
EUR 385.32

Accu-Tell COVID-19 IgG/IgM Rapid Test

GEN-B352-20tests 20 tests
EUR 283.2
Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus.

Accu-Tell COVID-19 IgG/IgM Rapid Test

GEN-B352-40tests 40 tests
EUR 385.2
Description: A rapid test for detection of antibodies (IgG and IgM) for 2019-nCoV, the novel Coronavirus from the Wuhan strain. The test is easy to perform, takes 10 minutes to provide reliable results and is higly specific to the 2019-nCoV Coronavirus.

NOVATest IgG/IgM Antibody Rapid Test Kit (NOVA Test)

UNCOV-40 40 Tests
EUR 115

Mouse S1PR2(Sphingosine 1-phosphate receptor 2) ELISA Kit

EM0370 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 46.875pg/ml

Mouse S1PR3(Sphingosine 1-phosphate receptor 3) ELISA Kit

EM0371 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 37.5pg/ml

Mouse S1PR1(Sphingosine 1-phosphate receptor 1) ELISA Kit

EM0608 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Mouse Sgpl1(Sphingosine-1-phosphate lyase 1) ELISA Kit

EM0638 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Mouse S1PR4(Sphingosine 1 Phosphate Receptor 4) ELISA Kit

EM1341 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 46.875pg/ml

Mouse S1PR5(Sphingosine 1 Phosphate Receptor 5) ELISA Kit

EM1342 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 46.875pg/ml

Rat S1pr5(Sphingosine 1-phosphate receptor 5) ELISA Kit

ER0279 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.094 ng/ml

Human S1PR2(Sphingosine 1-phosphate receptor 2) ELISA Kit

EH0848 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human S1PR3(Sphingosine 1-phosphate receptor 3) ELISA Kit

EH0849 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human S1PR4(Sphingosine 1-phosphate receptor 4) ELISA Kit

EH0850 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.075 ng/ml

Human S1PR5(Sphingosine 1-phosphate receptor 5) ELISA Kit

EH0851 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 46.9pg/ml

Human G6PD(Glucose-6-phosphate 1-dehydrogenase) ELISA Kit

EH1022 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.188 ng/ml

Human SGPP1(Sphingosine-1-phosphate phosphatase 1) ELISA Kit

EH1275 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Human S1PR1(Sphingosine 1-phosphate receptor 1) ELISA Kit

EH1597 96T
EUR 681.12
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit

CAS400A-KIT 1 kit (10 rxn)
EUR 1332

Pesticide Kit Containing All 10 Multi-Compound Mixes

SPXPR-KIT 1ML
EUR 1923.18

Test product

testtt 0 Ask for price

CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV100PA-KIT 1 Kit
EUR 1358.4

CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV105PA-KIT 1 Kit
EUR 1358.4

MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV120PA-KIT 1 Kit
EUR 1358.4

MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit

CASLV125PA-KIT 1 Kit
EUR 1358.4

Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS700A-KIT 10 rxn
EUR 1358.4

Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS720A-KIT 10 rxn
EUR 1358.4

Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector

CAS740A-KIT 10 rxn
EUR 1358.4

NOVATest Antigen Rapid Test Kit (For Single Use) (NOVA Test)

nCov-500-01 1T
EUR 162

T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents)

CAS510A-KIT 1 Kit
EUR 966

Mouse NOX4(Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4) ELISA Kit

EM1238 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA ;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Rat Nox4(Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4) ELISA Kit

ER0541 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.188 ng/ml

Rat Nox1(Nicotinamide Adenine Dinucleotide Phosphate Oxidase 1) ELISA Kit

ER0687 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Rattus;Sensitivity: 0.188 ng/ml

Recombinant human Phosphate-regulating neutral endopeptidase

P2180 100ug Ask for price
Description: Recombinant protein for human Phosphate-regulating neutral endopeptidase

Cas9 Nickase: CMV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV200PA-KIT 1 Kit
EUR 1358.4

Cas9 Nickase: CMV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV205PA-KIT 1 Kit
EUR 1358.4

Cas9 Nickase: MSCV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV220PA-KIT 1 Kit
EUR 1358.4

Cas9 Nickase: MSCV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit

CASLV225PA-KIT 1 Kit
EUR 1358.4

Multiplex gRNA Kit + Cas9 Nickase: EF1-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS750A-KIT 10 rxn
EUR 1358.4

Multiplex gRNA Kit + Cas9 Nickase: CAG-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS770A-KIT 10 rxn
EUR 1358.4

Multiplex gRNA Kit + Cas9 Nickase: CMV-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector

CAS790A-KIT 10 rxn
EUR 1358.4

Cas9 SmartNuclease Extra Ligation Kit [includes 5x ligation buffer (10 ul) and Fast ligase (2.5ul)]

CAS9LIG-KIT 1 Kit
EUR 183.6

Histamine Assay Kit

AKR-360 96 assays
EUR 622.8
Description: Histamine is naturally occurring in food, with high concentrations associated with spoiled and fermented foods. Exposure to high levels of histamine through the ingestion of food can cause symptoms similar to an allergic response. Our Histamine Assay Kit detects total histamine from food samples using a colorimetric probe. Reduction of the probe yields color development proportional the histamine levels in the sample. Absorbance at 450nm is read after a one hour incubation at 37C and histamine levels are calculated based on a histamine standard curve.

Glycosaminoglycans Assay Kit

6022 1 kit
EUR 503.7
Description: Glycosaminoglycans Assay Kit

DNA Assay Kit

6023 1 kit
EUR 216.6
Description: DNA Assay Kit

Hemoglobin Assay Kit

6024 1 kit
EUR 216.6
Description: Hemoglobin Assay Kit

Proteasome Assay Kit

55R-1341 100 assays
EUR 784.8
Description: Assay Kit for detection of Proteasome in the research laboratory

Calpain Assay Kit

55R-1342 100 assays
EUR 934.8
Description: Assay Kit for detection of Calpain in the research laboratory

Glutathione Assay Kit

55R-1343 100 assays
EUR 784.8
Description: Assay Kit for detection of Glutathione in the research laboratory

Glutathione Assay Kit

55R-1354 100 assays
EUR 1074
Description: Assay Kit for detection of Glutathione activity in the research laboratory

HDAC Assay Kit

55R-1371 100 assays
EUR 807.6
Description: Assay Kit for detection of HDAC in the research laboratory

HDAC Assay Kit

55R-1372 100 assays
EUR 807.6
Description: Assay Kit for detection of HDAC in the research laboratory

HAT Assay Kit

55R-1373 100 assays
EUR 888
Description: Assay Kit for detection of HAT in the research laboratory

SOD Assay Kit

55R-1374 100 assays
EUR 722.4
Description: Assay Kit for detection of SOD in the research laboratory

HDAC3 Assay Kit

55R-1377 100 assays
EUR 831.6
Description: Assay Kit for detection of HDAC3 in the research laboratory

HDAC8 Assay Kit

55R-1379 100 assays
EUR 826.8
Description: Assay Kit for detection of HDAC8 in the research laboratory

ATP Assay Kit

55R-1380 100 assays
EUR 970.8
Description: Assay Kit for detection of ATP in the research laboratory

ADP Assay Kit

55R-1381 100 assays
EUR 970.8
Description: Assay Kit for detection of ADP in the research laboratory

FAD Assay Kit

55R-1382 100 assays
EUR 878.4
Description: Assay Kit for detection of FAD in the research laboratory

PEP Assay Kit

55R-1384 100 assays
EUR 1051.2
Description: Assay Kit for detection of PEP in the research laboratory

Ammonia Assay Kit

55R-1388 100 assays
EUR 888
Description: Assay Kit for detection of Ammonia in the research laboratory

cAMP Assay Kit

55R-1389 100 assays
EUR 847.2
Description: Assay Kit for detection of cAMP activity in the research laboratory

cGMP Assay Kit

55R-1390 100 assays
EUR 847.2
Description: Assay Kit for detection of cGMP activity in the research laboratory

Urea Assay Kit

55R-1391 100 assays
EUR 888
Description: Assay Kit for detection of Urea in the research laboratory

Calcium Assay Kit

55R-1392 250 assays
EUR 703.2
Description: Assay Kit for detection of Calcium activity in the research laboratory

Magnesium Assay Kit

55R-1393 100 assays
EUR 784.8
Description: Assay Kit for detection of Magnesium in the research laboratory

Zinc Assay Kit

55R-1394 100 assays
EUR 807.6
Description: Assay Kit for detection of Zinc in the research laboratory

Iron Assay Kit

55R-1395 100 assays
EUR 909.6
Description: Assay Kit for detection of Iron in the research laboratory

JNK Assay Kit

55R-1407 40 assays
EUR 1041.6
Description: Assay Kit for detection of JNK in the research laboratory

JNK Assay Kit

55R-1408 40 assays
EUR 1174.8
Description: Assay Kit for detection of JNK in the research laboratory

Akt Assay Kit

55R-1409 40 assays
EUR 1174.8
Description: Assay Kit for detection of Akt in the research laboratory

Ammonia Assay Kit

55R-1410 100 assays
EUR 888
Description: Assay Kit for detection of Ammonia in the research laboratory

Cobalt Assay Kit

55R-1435 100 assays
EUR 745.2
Description: Assay Kit for detection of Cobalt in the research laboratory

Nickel Assay Kit

55R-1436 100 assays
EUR 745.2
Description: Assay Kit for detection of Nickel in the research laboratory

Chloride Assay Kit

55R-1437 100 assays
EUR 580.8
Description: Assay Kit for detection of Chloride in the research laboratory

Aspartate Assay Kit

55R-1438 100 assays
EUR 807.6
Description: Assay Kit for detection of Aspartate in the research laboratory

Hydroxyproline Assay Kit

55R-1439 100 assays
EUR 1012.8
Description: Assay Kit for detection of Hydroxyproline in the research laboratory

Phenylalanine Assay Kit

55R-1442 100 assays
EUR 784.8
Description: Assay Kit for detection of Phenylalanine in the research laboratory

Phosphatidylcholine Assay Kit

55R-1443 100 assays
EUR 807.6
Description: Assay Kit for detection of Phosphatidylcholine in the research laboratory

Glucose Assay Kit

55R-1449 100 assays
EUR 847.2
Description: Assay Kit for detection of Glucose in the research laboratory

Lactate Assay Kit

55R-1450 100 assays
EUR 1012.8
Description: Assay Kit for detection of Lactate in the research laboratory

Pyruvate Assay Kit

55R-1452 100 assays
EUR 1012.8
Description: Assay Kit for detection of Pyruvate in the research laboratory

Adipogenesis Assay Kit

55R-1454 100 assays
EUR 703.2
Description: Assay Kit for detection of Adipogenesis in the research laboratory

Glucose Assay Kit

55R-1458 100 assays
EUR 888
Description: Assay Kit for detection of Glucose in the research laboratory

Galactose Assay Kit

55R-1459 100 assays
EUR 888
Description: Assay Kit for detection of Galactose in the research laboratory

Maltose Assay Kit

55R-1460 100 assays
EUR 867.6
Description: Assay Kit for detection of Maltose in the research laboratory

Fructose Assay Kit

55R-1461 100 assays
EUR 826.8
Description: Assay Kit for detection of Fructose in the research laboratory

Ethanol Assay Kit

55R-1462 100 assays
EUR 928.8
Description: Assay Kit for detection of Ethanol in the research laboratory

Galactose Assay Kit

55R-1463 100 assays
EUR 847.2
Description: Assay Kit for detection of Galactose in the research laboratory

Lactose Assay Kit

55R-1466 100 assays
EUR 847.2
Description: Assay Kit for detection of Lactose in the research laboratory

Creatinine Assay Kit

55R-1467 100 assays
EUR 765.6
Description: Assay Kit for detection of Creatinine in the research laboratory

Sucrose Assay Kit

55R-1468 100 assays
EUR 826.8
Description: Assay Kit for detection of Sucrose in the research laboratory

Lactate Assay Kit

55R-1469 100 assays
EUR 1012.8
Description: Assay Kit for detection of Lactate in the research laboratory

Maltose Assay Kit

55R-1470 100 assays
EUR 847.2
Description: Assay Kit for detection of Maltose in the research laboratory

Rising Novel Coronavirus is a International Menace: Perception within the Biology of COVID-19 and its Hijacking Means of Hosts’ Cell 

The outbreak of novel corona virus (2019-nCoV) has unfold out globally. If we glance again in 1960 when first look of the corona virus (CoV) occurred, it was thought of non-virulent. Forty-two years later, individuals grew to become contaminated with an unknown virus in Guangdong province in China, displaying signs of extreme acute respiratory syndrome (SARS), after genomic evaluation, CoV was detected however there was additionally a drastic genomic change in between SARS-CoV and CoV that was present in 1960.

Thereafter, it broke out once more in 2012 because the (MERS-CoV) and 2019 (2019-nCoV). These genomic transformations are related to mutation which favors the CoV for evolution and with higher adaptation using hijacking focused host cells extra appropriately in direction of quicker transcription and replication, and infect human by transmission via direct or oblique contact of the contaminated people via inhaling droplets originated by coughing or sneezing in contaminated individuals.

CoV begins replicating by a brand new host thus, the potential reason for the genomic transformation of every new CoV-strain is the higher adaptation and better virulence. On this regards the newest pressure of extreme acute deficiency syndrome-coronavirus-2 (SARS-CoV-2) might be extra deadly. For correct understanding, on this assessment, we implicated how CoV binds to host receptors, and we offer temporary introduction of the mutation, replication, transmission and pathogenicity of this virus. All of those phases of coronavirus are very important for his or her distinctive evolution.

Motile cilia genetics and cell biology: massive outcomes from little mice 

Our understanding of motile cilia and their function in illness has elevated tremendously during the last twenty years, with important data and perception coming from the evaluation of mouse fashions. Motile cilia type on particular epithelial cell sorts and usually beat in a coordinated, whip-like method to facilitate the movement and clearance of fluids alongside the cell floor.

Defects in formation and performance of motile cilia lead to major ciliary dyskinesia (PCD), a genetically heterogeneous dysfunction with a well-characterized phenotype however no efficient remedy. Numerous mannequin techniques, starting from unicellular eukaryotes to mammals, have offered details about the genetics, biochemistry, and construction of motile cilia.

Nevertheless, with outstanding assets out there for genetic manipulation and developmental, pathological, and physiological evaluation of phenotype, the mouse has risen to the forefront of understanding mammalian motile cilia and modeling PCD. That is evidenced by numerous related mouse traces and an intensive physique of genetic and phenotypic information.

Extra not too long ago, software of modern cell organic strategies to those fashions has enabled substantial development in elucidating the molecular and mobile mechanisms underlying the biogenesis and performance of mammalian motile cilia. On this article, we are going to assessment genetic and cell organic research of motile cilia in mouse fashions and their contributions to our understanding of motile cilia and PCD pathogenesis.

 

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